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Abstract

INFLUENCES OF PROCESSING METHOD, FILLER TYPE AND APPLIED COMPRESSION FORCE ON PHARMACEUTICAL PROPERTIES OF KETOPROFEN ORAL MATRICES.

Abubakr O. Nur*, Waleed Elballa, Zuheir A. Osman, Mohamed Abdeen

ABSTRACT

The aim of this study is to investigate the possible individual and joined influences of processing method, filler type and applied compression force on the physical performance of HPMC based oral matrices using ketoprofen as a model drug. Design implemented was 3(3-1) fractional factorial design where each of the investigated variables was examined at 3 different levels. Matrix tablets were prepared according to the design and were evaluated for their weight variation, friability and drug release properties. Results indicated that processing method and filler type were found to influence weight variation, friability and drug release attributes of different matrices either through their individual or joined effects (p< 0.05). Moreover, the joined influences of processing method and filler type on weight variation and friability properties were shown to be comparable to the negligible influence of the applied compression force on both properties. Whilst the influence of applied compression force on time for 50% drug release and dissolution efficiency properties of different matrices was proved to be profound (p= 0.0154), drug release kinetics (n) appeared to be the least affected matrix property by any of the variables investigated. The study highlighted the supremacy of the joined influence of processing method and filler type on different matrix properties in comparison to the individual influences of each variable alone, at least within the experimental domain of the present study.

Keywords: Fractional factorial design, processing method, filler type, applied compression force, HPMC matrices, individual and joined influences.


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