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Abstract

ANTI-DIABETIC ACTIVITY OF POLYHERBAL FORMULATION ON ALLOXAN INDUCED RATS

Rajput Rekha*1, Chandra Amrish2

1Bhagwant University, Ajmer, India
2Amity Institute of Pharmacy, Amity university, Uttar Pradesh, 201031, India.

ABSTRACT

The polyherbal anti-diabetic formulation is prepared in solution form by mixing the water and alcoholic extract of five medicinal plants indigenous in India. The polyherbal formulation was evaluated for its anti-diabetic effect at two different doses. The anti-hyperglycemic effect of formulation found nearly comparable with glibenclamide which is used as standard drug to compare the anti-diabetic effect of formulation at different doses by using the glucometer to measure the blood glucose level. It was found that the anti-diabetic activity of formulaion at a dose of 400mg/kg of body weight (294.5 1.40) more effective than 200mg/kg of body weight (297.33 0.76) on wistar albino rats. So it was concluded that the anti-diabetic activity of polyherbal formulation in solution form is nearly comparable with standard drug glibenclamide(261.5 0.56) and the formulation at the dose of 400mg/kg was showed more significant anti-diabetic effect at 1st hour(359.16 1.42) after drug administration and at the dose of 200mg was showed more significant effect at 2nd hours(354 0.57) when its compare with the control group (363.830.5 and 3760.63 for 1st and 2nd hours respectively) on wistar albino rats. It was also concluded that the formulation have significant anti-diabetic activity and also stable till the 3 month which was observed by the stability testing by using different parameters used for evaluation of solution.

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