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Abstract

LC-MS/MS STUDIES ON THE FRUIT EXTRACTS OF MORINDA CITRIFOLIA L (NONI)

Paul Pandi T*, Selvam P and Rama Mohan GupthaV

ABSTRACT

Introduction: Morinda citrifolia L (Noni) has been extensive history of medicinal uses among the traditional therapeutic action in 2000 years ago. It’s belongs to Rubiaceae family and commonly known as Indian Mulberry. Commercially Noni fruit is functional and widely distributed in throughout Andaman, Pacific islands and Indian coastal areas. Noni has reported broad spectrum of Pharmacological activity like anti-bacterial, anti-fungal, anti-hepatoprotective, anti-tumor, antitubercular, wound healing, immunological and anti-viral activity. The Noni fruit containing enriched secondary metabolites like Anthroquinones, Flavonoids, alkaloids, amino acids, vitamins and glycosides. Objective: The present study is carried out to prepare extracts from Noni fruit by using different solvents such as Pet. Ether, Acetone, Ethyl acetate, Ethanol and Methanol. Continues to analyse preliminary phytochemical screening and identify the bioactive phytoconstituents in Noni fruit extracts by LC-MS/MS method. Methodology: The air dried Noni fruit powder was subjected to hot continues extraction by using Soxhlet apparatus with range of non-polar to polar solvents such as Pet. Ether (MCF-Pet. Et), Acetone (MCF-Ac), ethyl acetate (MCF-EtoAc), ethanol (MCF-Et) and methanol (MCF-Me). Preliminary Phytochemical analysis and identification of active constituents confirmed by modern Liquid Chromatography-mass spectrometry (LCMS/ MS) technique. Results: The crude extracts obtained from the Morinda citrifolia fruit with different solvents subjected to successive extraction. The preliminary phytochemical analysis of different solvent extracts of Noni shows all common secondary metabolites. The presences of bioactive constituents were confirmed by LC-MS/MS technique and test samples are compared with reference standard compounds. We are reporting first time in presence of Rutin, Quercetin, Kaempferol, Scopoletin and Rubiadin 1-methyl ether in ethanol (MCF-Et) and methanol (MCF-Me) extracts. Conclusion: Phytochemical studies showed that Noni fruit confined a wide spectrum of secondary metabolites such as Carbohydrates, Alkaloids, cardiac glycosides; flavonoids were found in MCF-EtoAc, MCF-Et and MCF-Me extracts, where sterols and proteins are found in MCF-Pet. Et and MCF-Ac extracts. This study intensely supports the use of M. Citrifolia (Noni) constituent’s Rutin, Kaempferol and Quercetin posses as an anti-viral activity and Immune-enhancing properties.

Keywords: Morinda citrifolia, phytochemical, LC-MS/MS, Rutin, Quercetin, Kaempferol, Scopoletin, Rubiadin 1-methyl ether.


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