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Abstract

STUDY THE ROLE OF OBESITY AND OXIDATIVE STRESS AS FACTORS OF TYPE 2 DIABETES

Edrees M.Ameen*, Hassan Y. Muhammad and Sabah N. Alwachi

ABSTRACT

Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period It is known that type 2 diabetes mellitus and obesity are bound common metabolic problems. The adipokines or adipocytokines are cytokines (cell signaling proteins) secreted by adipose tissue, their action is thought to modify many obesity-related diseases. Oxidative stress (malondialdehyde the final result of lipid peroxidation is considered a biomarker of oxidative stress) is another underlying cause of inflammation in type-2 diabetes (T2DM) playing a central role in causing late diabetic complications such as insulin resistance and impaired insulin secretion in T2DM. Materials and Methods: In the present study, 140 males with the ages between (30-60) years, 90 males of them diagnosed with diabetes type 2 and 50 of them were used as control groups. The subjects were divided into four groups, group (I) control, noneobese (25 samples): group (II) control, obese (25 samples); group (III) none-obese diabetic patients (45 samples), group (IV) obese diabetic patients (45 samples). The parameters in the present study were included Adipokines (Leptin, Resistin, and Apelin) and Malondialdehyde. Results: The study showed a highly significant (P<0.05) increased in Leptin, Resistin, Apelin in diabetic groups (none-obese and obese) when compared with control groups, with the higher concentration of them were observed in obese diabetic group. The results demonstrated a highly prevalence of abnormal concentration of leptin, Resistin in diabetic groups compared with control groups. Furthermore the results found significant positive correlation between these Adipokines together and with Body mass index (BMI). Regarding oxidative stress, the results showed a significant increase (P<0.05) in serum Malondialdehyde (MDA) concentration in obese control, none-obese diabetic and obese diabetic groups when compared with none-obese control group, and higher concentration of MDA were recorded in diabetic obese group. Positive correlation were found between MDA with body mass index, leptin, Apelin and resistin in type 2 diabetes.

Keywords: Type-2 diabetes, Obesity, Adipokines, Leptin, Resistin, Apelin, Oxidative stress, Malondialdehyde.


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