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Abstract

FORMULATION AND EVALUATION OF BUCCOADHESIVE DISKS OF BENZOCAINE

Gamal M. Mahrous*

ABSTRACT

Buccoadhesive erodible disks of benzocaine were prepared using different bioadhesive polymers along with excipients like mannitol. The optimized disk containing 30.0 mg of benzocaine, 1.5 mg of sodium stearyl fumarate and 90.0 mg of mannitol along with carbopol 934P, 30mg was found to release the drug for a period of over 6.0 h without getting dislodged. Maximum in vitro drug release was found to be 60.0% in 6.0-h study. In situ release characteristics were evaluated using a „flow-through assembly‟, which simulated the conditions of the human buccal cavity. The drug concentrations in the in situ samples were found to be above (10ug/ml) of the drug up to 6 hours. The physico chemical properties, bioadhesive performance and the surface pH of the disks were satisfactory.

Keywords: Buccoadhesive, stearyl fumarate, mannitol, carbopol.


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