WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

TOXICOLOGICAL STUDIES OF ETHANOLIC LEAVES EXTRACT OF SARCOSTEMMA VIMINALE

Moussa Yahaya, *Angela Nnenna Ukwuani, Caleb Francis

ABSTRACT

The effects of Sarcostemma viminale leaves extract on the
haematological, toxicological and histopathological indices were
evaluated in rats. The extracts at a single dose of 5000 mg/kg did not
produce any behavioural sign of toxicity or mortality in any of the
animals tested during 14 days observation period and as such, LD50 of
this plant was estimated to be greater than 5000 mg/kg. In the 28days
repeated dose oral sub-chronic toxicity study, administration of 250,
500 and 1000 mg/kg body weight Sarcostemma viminale leaves
extracts revealed no significant difference (p>0.05) in the
haematological parameters. Analysis of biochemical parameters
reveals no significant difference (p>0.05) in the extract treated groups
when compared to the control group. The histopathological
examination of the treated groups showed no visible lesions or signs of
the liver damage while the kidney revealed tubular congestion and necrosis, focal
haemorrhage and hyaline degeneration. These results suggest that the sub-chronic
administration of ethanolic extracts of Sarcostemma viminale leaves has no marked toxic
effect on the liver while unmasking the possible dangers of this plant to the kidney.

Keywords: Toxicity, Sarcostemma viminale, leaves extracts, ethanolic.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More