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Abstract

EVALUATION OF ANTI-DIABETIC ACTIVITY OF WHOLE PLANT OF TRIUMFETTTA RUTONDIFOLIA LINN IN STREPTOZOTOCININDUCED DIABETIC RATS

R.Sanilkumar* and A.Kottai Muthu

Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, India.

ABSTRACT

The anti-diabetic activity of methanolic extract of Triumfetta rotundifolia Linn;(Liliaceae) in streptozotocin induced diabetic rats was investigated in the present study. Streptozotocin was used to induce diabetes mellitus. The anti-diabetic potential was assessed by determining oral glucose tolerance, fasting blood glucose, urine glucose, liver glycogen content, serum lipid profile, change in body weight and histopathology studies. Methanolic extract was administered to normal and experimental diabetic rats for 15 days. Significant (p<0.001) reduction in fasting blood glucose levels was observed in the methaolic extracts is treated diabetic animals from day 7 onwards. In oral glucose tolerance test, reduction in fasting blood glucose a level was noted after 60 min of extract administration. After 15 days of treatment with extracts the maximum reduction in fasting blood glucose (53.87%) was observed in diabetic rats treated with methanolic extract of Triumfetta rotundifolia (200mg/kg/body wt). Serum lipid levels reversed towards near normal and the loss of body weight was controlled in treated rats as compared to diabetic control. The extract treatment also showed a significant increase in the liver glycogen content and gradual decrease in level of urine sugar level of sugar level. Microscopically examined pancreas section of rats treated with 200mg/kg methanolic extract showed normal architecture of pancreas. The results demonstrate that whole plant of Triumfetta rotundifolia possesses significant anti-diabetic activity. The results suggest that Triumfetta rotundifolia has anti-diabetic activity, thereby justifying its traditional use.

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