WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FABRICATION AND EVALUATION OF ANTI- DIABETIC SUSTAINED RELEASE HERBAL TABLETS

Parasuram Rajam Radhika *, Niranjan Ravur, Ravela Navya Durga

ABSTRACT

The present study was to fabricate and evaluate oral anti- diabetic sustained release herbal tablets by direct compression method with dry extracts of Costus Pictus., Trigonella Foenum- Graecum and Abelmoschus Esculentus were used as the polymers and binding agent respectively in the preparation of Costus Pictus sustained release tablets.Costus Pictus were subjected for isolation and identification of active compound. The isolated compound were identified by UV, IR, Mass and NMR spectroscopy and the compound identified as the β- Amyrin of triterpenoids, which may be responsible for the anti diabetic activity. Physico chemical properties of dried powdered blend were studied. Prepared tablets were evaluated for thickness, hardness, friability, uniformity of weight, swelling behavior and release ate characteristic were studied. The extract of Trigonella Foenum- Graecum and Abelmoschus Esculentus showed sustained release of the drug Costus Pictus with the concentration of 15 % of the binder and the polymer. The in-vitro release data was applied to various kinetic models and the optimized formulation (F6) was to follow zero order kinetics. In- vivo studies were done to evaluate anti diabetic activity in rabbits and the formulation F6 was found to be the best among all the formulation. Studies indicated that the extracted drugs is a good pharmaceutical adjuants and possess anti – diabetic activity. Finally it is concluded that the herbal tablets of Costus Pictus has reduced side effects, low cost and improved bio availability of the drug.

Keywords: Costus Pictus, Trigonella Foenum- Graecum and Abelmoschus Esculentus, Controlled release., Matrix Tablets.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More