WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

SYNTHESIS OF POTENTIAL & BIOLOGICALLY ACTIVE PYRIMIDINE HYDRAZONES DERIVATIVES

Sanchit Srivastav, Dr. Md Akram Minhaj*, Manoj Kumar Prabhakar, Kanishk Luhach

ABSTRACT

The development of innovative compounds, pyrimidine hydrazones have been shown to possess a diverse variety of biological activities viz. antimicrobial, anticonvulsant, anti-oxidant, anti-inflammatory, analgesic, antimalaral, anticancer, antiviral, cardio protective etc., Pyrimidine constitutes an important class of heterocycles in drug discovery. Hydrazones is a class of organic compounds with the structure R1R2C=NNH2. They are formed usually by the action of hydrazine on ketones or aldehydes & have efficient CNS depressant, analgesics activity. In the same context, Schiff bases of pyrimidne hydrazones were prepared by the reaction of “4-(4-Chloro-phenyl)-6- methyl-2-oxo-1, 2, 3, 4-tetrahydro-pyrimidine-5-carboxylic acid hydrazideâ€Â with citral, camphor, furfuraldehyde & menthone individually by refluxing them in the presence of glacial acetic acid (as solvent) for at least 2hrs to yield their respective derivatives. The present studies revealed that Pyrimidine hydrazone derivatives could be used to synthesize the compounds having potent biological activities such as anticancer, antimicrobial, antioxidant, CNS depressant, analgesic & antiviral activities. All the prepared derivatives were under investigation for their antimicrobial activity and likely to posses the same & desired action.

Keywords: Pyrimidine Hydrazones, antimicrobial, antioxidant and Schiff Bases.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More