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Abstract

FORMULATION AND EVALUATION OF ZIDOVUDINE SUSTAINED RELEASE MATRIX TABLETS USING MANILKARA ZAPOTA GUM AS A RELEASE RETARDING POLYMER

Dr M.Sunitha Reddy* and Deepthi Dabbeta

ABSTRACT

The present study was aimed to develop sustained release matrix tablets of Zidovudine using manilkara zapota gum as a matrix forming hydrophilic polymer. Manilkara zapota gum is a natural drug release rate modifier extracted from the fresh ripens fruits of sapota. Due to the short half life (0.5±3 hrs) Zidovudine sustained release once daily tablet formulation could be used to maintain optimum peak plasma concentration for effective viral suppression. The Zidovudine matrix tablets were prepared by wet granulation method using manilkara zapota gum as a release retarding polymer and polyvinylpirrolidone as a binder. Five formulations of different polymer percentages were formulated, F1 (15%), F2 (25%), F3 (30%), F4 (33%), F5 (25%) is a combination of HPMC: manilkara zapota gum (1:1). The physicochemical characteristics of Zidovudine tablets such as FTIR, melting point, and pre-compression parameters and post-compression parameters were evaluated. All the parameters were found to be within the limits. The dissolution studies were performed using USP apparatus type-II using pH 6.8 phosphate buffer as dissolution medium. These studies showed that formulation F2 consisting of 25% of polymer was found to sustain the release of Zidovudine over a period of 12hrs. The dissolution results show that the increase in gum concentration decreases the drug release.

Keywords: Manilkara zapota gum, Zidovudine, matrix tablet.


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