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Abstract

FORMULATION AND EVALUATION OF PRESS COATED TABLET OF ACELOFENAC SOLID DISPERSION PREPARED USING MICROWAVE INDUCED FUSION METHOD

*Kazi M. S., Chishti N., Shaikh N.,

ABSTRACT

The aim of present investigation was to develop press coated tablet of Aceclofenac solid dispersion (SD) for obtaining pulsatile drug release. The drug delivery system was designed to deliver the drug at such a time when it could be most needful to patient of rheumatoid arthritis. Solid Dispersion of Aceclofenac using PVP K-30 as a carrier was prepared by kneading method, solvent evaporation method and microwave fusion technique. Solid dispersions prepared using microwave fusion technique was further selected to prepare press coated tablets, containing Aceclofenac SD in the inner core and different amounts of HPMC K4M as the outer coating material. The release profile of press coated tablet exhibited a lag time depending upon the amount of HPMC K4M in compression coating, followed by burst release. Optimization was done using 32 factorial design considering two independent factors at three levels. Data was evaluated statistically by Stat Ease Design Expert 7.1.4 software. The optimized batch F6 gave a lag time of 6 hr and drug release of 98.58% which consisted of 4% crosspovidone and 36% HPMC K4M. The Chronodelivery of Aceclofenac SD was achieved by formulating the tablet by compression coating technique.

Keywords: Press Coated Tablet, Chronotherapy, Solid Dispersion, Microwave Fusion Method, Aceclofenac.


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