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Abstract

DEVELOPMENT AND EVALUATION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRIX TABLETS EMPLOYING NATURAL POLYMERS

G. Sravan Kumar*1, M. Srinivasa Rao2, B. Kishore Kumar Reddy3, K. Suresh Kumar4, S.V.N. Gangadhar5

1Department of Pharmaceutics, Vagdevi College of Pharmacy, Gurajala, Guntur Dist, A.P, India.
2Department of Quality Assurance, Beloorbayirbiotec Ltd., Tumkur, Karnataka, India.
3Department of Pharmaceutics, A.K.R.G College of Pharmacy, Nallagerla, W.G.Dist, A.P, India.
4Department of Pharmaceutics, University College of Pharmacy, JNTU Kakinada, E.G. Dist, A.P, India.
5Department of Pharmaceutics, Adarsha College of Pharmacy, Kottapalli, E.G.Dist, A.P, India.

ABSTRACT

Oral route of administration is the most widely accepted route of delivery due to the ease of administration, avoidance of pain and other risks of parenteral administration and has a good patient compliance. The aim of current research work is to design and characterize sustained release matrix tablets of Diclofenac sodium employing natural polymers like Tamarind seed polysaccharide (TSP) and Guar gum in view to improve therapeutic action and patient compliance by reducing dosage frequency. TSP and Guar gum are individually checked for sustaining the drug release at different concentrations ranging 10%-35% of tablet weight. A drug excipient compatibility study performed by FTIR spectroscopy. Total 12 formulations were developed, which were evaluated for parameters like thickness, hardness, frialbility, swelling index, uniformity of weight, assay and in vitro drug release. The two optimized formulations F5 containing 30% of TSP and F12 containing 35% of Guar gum were successful in sustaining the release of Diclofenac sodium for 12hrs. The results suggest that the developed sustained release matrix tablets prepared employing TSP and Guar gum of Diclofenac sodium could perform better than conventional dosage forms, leading to improve efficacy and better patient compliance.

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