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Abstract

METHOD DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR THE DETERMINATION OF LERCANIDIPINE

Dr. M. Sunitha Reddy*, Navya Sai.K, S. Muhammad Fazal Ul Haq

ABSTRACT

Lercanidipine is a calcium channel antagonist used as antihypertensive agent. A suitable spectroscopic method which is specific,accurate,and precise, has been developed for the determination of lercanidipine.The solvent used is methanol and ╬╗max is found to be 239nm.The method is highly sensitive and linearity is observed at 5ppm to 25ppm.Regression equation is found to be y = 0.03566 x + 0.00620. The method is validated for various parameters like precision, accuracy, robustness,detection and quantification limits. The results shows that method is precise accurate, reproducible,simple,cheap and less time cosuming. This method can be suitable for determination of lercanidipine in bulk formulation.

Keywords: lercanidipine, method development, spectroscopic method, validation


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