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Abstract

“EVALUATION OF ANTIDEPRESSANT ACTIVITY OF AQUEOUS EXTRACT OF ROOTS OF ACORUS CALAMUS IN ALBINO MICE”.

Dr. Shashikala GH, Dr. Prashanth D*, Dr. Jyothi CH, Dr. Imran Maniyar, Dr. Manjunath H

ABSTRACT

Objectives: To evaluate the antidepressant activity of aqueous extract of Acorus calamus in mice. Materials and Methods: A total of 72 albino mice were included in the study. Six groups of six animals in each group were taken in each of the behavior despair models [forced swimming model (FSM) and tail suspension model (TSM)]. Three groups of mice received aqueous extract of Acorus calamus (at doses 100, 150, 200 mg/ kg body weight), two groups received standard drugs (imipramine 15 mg/kg and fluoxetine 10 mg/kg) and control group received normal saline. Antidepressant activity (i.e., Immobility time) was assessed after 30 minutes of administration of drugs intraperitoneally. Data was analyzed by ANOVA statistical test (with p<0.05) followed by Tukey’s Post Hoc Analysis. Results expressed as Mean ± SEM. Results: In FSM, test drug groups (100 mg 78.8±15.3 s, 150 mg 88.5±19.3 s, 200 mg 94.7±16.6 s) and both the standard drug groups (imipramine 91.8±8.4 s, fluoxetine 84.8±14.4 s) showed significant reduction in immobility time when compared to control group (141.3±5.6 s) (p<0.05). The immobility time of the test drug groups and standard drug groups were comparable to each other. In TSM, only imipramine group (109.0±10.6 s) and test drug 200 mg/kg group (104.7±5.7 s) showed statistically significant reduction (p<0.05) in immobility time when compared to control group (144.0±9.3 s). However, the other two test drug groups and fluoxetine group did not show a significant difference when compared to control and also with each other. Conclusion: The aqueous extract of roots of Acorus calamus has shown antidepressant activity when tested in FSM & TSM.

Keywords: Depression, Acorus calamus, Imipramine, Fluoxetine, Forced swim model and Tail suspension model.


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