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Abstract

STUDY OF ALTERATION IN SERUM LIPIDS BY LISINOPRIL AND PERINDOPRIL IN ALBINO RABBITS

Shruti Chandra*, Neeraj Kumar Agarwal, Renu Khanchandani, Rajeev Prajapat, I. P. Jain and S. P. Singh

ABSTRACT

Hypertension with dislipidemia is becoming a common morbidity, since ACE inhibitors are the first line of antihypertensive drugs so present study was undertaken with the aim to evaluate the possible effects of ACE inhibitor on lipid profile in albino rabbits. The study was conducted in the Deptt. of Pharmacology & Therapeutics, GSVM Medical college, Kanpur. Rabbits were divided into 2 groups with 12 in each group. After 2 weeks of adaptation rabbits were given cholesterol rich diet for 8 weeks. After that animals of group I were continued with the same cholesterol enriched diet along with Lisinopril (0.25mg/kg/day PO) and group II were fed with cholesterol enriched diet along with Perindopril (0.20mg/kg/day PO) for 6 weeks more. Lipid profile estimation (Serum Total cholesterol, serum HDL, serum LDL, serum Triglycerides and serum VLDL) was done at day 0, 60 and day 102 respectively. Statistical analysis was carried out by using paired ‘t’ test. Serum total cholesterol, triglycerides, HDL, LDL and VLDL cholesterol, were increased significantly (P<0.05) in both the groups after 60 days of cholesterol feeding. Group I (Lisinopril) showed significant decrease in serum total cholesterol and LDL levels. HDL and Triglycerides levels increased significantly. The VLDL levels were also found to be increased but not found significant. Same results were obtained by Rabbits of group II (Perindopril). It was concluded that ACE inhibitor e.g Lisinopril, Perindopril had a favourable effect on serum lipid profile by decreasing total cholesterol, increasing serum HDL level and decreasing LDL levels by inhibiting ACE enzyme and various other mechanisms.

Keywords: ACE inhibitors, serum lipid profile, albino rabbits.


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