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Abstract

THE THERAPEUTIC EFFICACY OF KATIRA GUM IN BURN INJURY HEALING

Priti Girotra*, Shailendra Kumar Singh

Department of Pharmaceutical Sciences, G. J. University of Sci. & Tech., Hisar, India.

ABSTRACT

Introduction: Katira gum, a natural polysaccharide, possesses anodyne property because of which, traditionally it has been used in the dressing of burns. The present study was undertaken for evaluation of the therapeutic efficacy of Katira gum in the management of burn injuries. Method: The animals were allocated into four groups of six animals each. Gels were formulated with Katira gum (3.75%), silver sulfadiazine as standard (1% with 1.5 % carbopol 934 as gel forming agent) and 1.5% carbopol gel was used as control. Starving the rats overnight, under ketamine anaesthesia, partial thickness burns were inflicted on their back. Group I was selected as control, Group II as test, Group III as standard and Group IV for the combination effects of Katira gum and silver sulfadiazine. The gels were applied topically, once daily from day 0 to the day of complete healing. The wound healing was evaluated for Period of epithelialization, percent wound contraction. and burn scar scale based on color. Results: A significant reduction (P<0.001), when compared to Group I and Group II, was observed in the burn wound contraction and period of epithelialization in case of group IV. Conclusion: The combination of Katira gum and silver sulfadiazine was found to be more effective than either of the two in the therapeutic management of burn injury.

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