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Abstract

GASRTORETENTIVE DRUG DELIVERY SYSTEM: AT A GLANCE

Khobare Abhijit D*, Patel Poonam, Anurag Kumar, Parolkar Bhagyashree, Dhepe Vashisht

ABSTRACT

recent years scientific and technological advancements have been made in the research and development of oral drug delivery. Because oral route provide ease of administration. Oral sustained drug delivery has limited gastric residence times. Differences in gastric physiology, such as gastric pH and motility exhibit both intra- and inter- subject variability which has significant impact on the gastric retention time and drug delivery behavior. Because of this formulation of stomach specific dosage forms are taken into consideration. Gastro retentive drug delivery systems (GRDDS) are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. Gastro retention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients. Controlled gastric retention of solid dosage form may be achieved by the mechanisms of floatation, mucoadhesion, sedimentation, expansion or by a modified shaped system. Several approaches are currently being used to prolong the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, high-density systems, and other delayed gastric emptying devices. In this review, the current and recent developments of FDDS, including patented delivery systems and marketed products, are discussed.

Keywords: Floating drug delivery system, Hydrodynamically balanced system, Gastroretention, Evaluation of FDDS.


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