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Abstract

COMPARATIVE DOCKING ANALYSIS OF MARINE RED ALGAE AGAINST HEPATOCELLULAR CARCINOMA (HCC) 1IJX PROTEIN

Senthilraja P. *1, Manikandaprabhu S.1, Manju J.1, Loganathan K.2, Arulprakash A.2, Prakash M.2

1Department of Zoology, Division of Bioinformatics, Annamalai University, Chidambaram, India.
2Department of Zoology, Annamalai University, Chidambaram, India.

ABSTRACT

Liver cancer is one of the most deadly deaths causing cancer leading third in the world. Hepatocellular carcinoma (HCC) starts from the main cell in the liver which is called hepatocytes. It is the most common types of primary liver cancer. Aberrant activation of several pathways such as EGFR, Ras/ERK, PI3K/MTOR, HGF/MET, Wnt, Hedgehog and apoptotic signaling induce the HCC. Wnt/β-catenin pathway is implicated in colon cancer and HCC. Unfortunately it constitutes the most undruggable pathway. Activation of Wnt pathway induces translocation of β-catenin into the nucleus, where it regulates specific oncogenes, including c-myc, cyclin D, and surviving. Mutations in β-catenin occur in and around 17% of cases. Natural compounds usually having biological activities are used for drug discovery and drug design. Many natural products have been clinically available as potent hepato-protective agents against commonly occurring liver diseases. With this reference we perform a docking analysis against HCC with marine red algae and we get the good docking energy value as -13.4575 for Pinnasterol compound.

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