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Abstract

RESPONSE TO FIRST- LINE QUADRUPLE AND SECOND - LINE QUADRUPLE H PYLORI ERADICATION THERAPY IN IRAQI PATIENTS WITH PEPTIC ULCER DISEASE

ZahraaAbdul Ghani M.A, Manal Khalid Abdulridha?, Akram Ajeel Najeb

ABSTRACT

Because the high prevalence and serious health burden of H. pylori infection, it is crucial to use a highly effective and well tolerated eradication regimen. The overall prevalence is high in developing countries and lower in developed countries and within areas of different countries. This prospective study involved newly diagnosed patients aged 15-70 years with peptic ulcer (DU or GU) confirmed by endoscopy and positive for H. pylori by (histological examination, stool antigen test and antibody test). Thirty patients received first line quadruple therapy (triple capsule (Pylera)®; with esomeprazole 20 mg) for 10 days, and 20 patients who failed for previously treatment with triple therapy were treated with second- line quadruple therapy for 10 days. The higher incidence of H. pylori positive was in male gender. Approximately 26% had family history of peptic ulcer disease. The per protocol analysis revealed 90% eradication rates in patients treated with first- line quadruple therapy, and 85% with second- line quadruple therapy. Better H. pylori eradication rates were in younger adult patients ˂ 50 years after both first- line and second- line regimen, and was significantly less successful in women compared to men after both regimen. According to the data obtained from Iraqi population we can conclude that second- line H. pylori eradication quadruple therapy is as effective as first- line quadruple therapy that can be used as a rescue therapy after failure of triple H. pylori regimen.

Keywords: H. pylori, Peptic Ulcer Disease, Gastric Ulceration, Duodenal Ulceration, Per-protocol intention to treat, Quadruple H. pylori regimen, Three-in-one capsules (pylera)®


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