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Abstract

DEVELOPMENT OF FORMULATION AND IN-VITRO EVALUATION OF GASTRO RETENTIVE FLOATING DRUG DELIVERY SYSTEM FOR NITRENDIPINE BILAYER TABLETS

P.Gopalakrishna*, B.Ramarao, G. Chiranjeevi, Ramyasri.S

ABSTRACT

The present study was carried out for developing the formulation of Floating bilayer tablets of Nitrendipine. IR and SR layers were compressed as direct compression method. IR and SR Layers were evaluated for pre and post compression studies. Those all studies were found to be within limits. From the dissolution data of Nitrendipine Immediate release Layer, IR2 formulation was shown maximum drug release at 15 min. i.e., 95.62%. Hence IR2 was concluded as optimized formulation for IR layer. From the dissolution data of floating bilayer tablets of Nitrendipine, FT5 (IR2&SR5) has shown good drug release 97.12% upto 12 hrs. SR5contain Locust bean gum. Optimised SR5 Layers were kept for release kinetic studies. SR5 Layer was following Kars mayer peppas release kinetics.

Keywords: Nitrendipine, IR layer, SR floating layer, Direct compression, Floating bilayer tablets.


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