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Abstract

DEVELOPMENT OF FORMULATION AND IN VITRO EVALUATION OF GASTRO RETENTIVE FLOATING DRUG DELIVERY SYSTEM FOR PINDOLOL BILAYER TABLETS

J. Manikanta*, Ramyasri.S, J, B.Ramarao, G.Chiranjeevi

ABSTRACT

The present study was carried out for developing the formulation of Floating bilayer tablets of Pindolol. IR layer was compressed as direct compression method and SR layer blends were compressed by wet granulation method. IR and SR Layers were evaluated for pre and post compression studies. Those all studies were found to be within limits. From the dissolution data of Pinodolol Immediate release Layer, IR4 formulation was shown maximum drug release at 20min. i.e., 96.58%. Hence IR4 was concluded as optimised formulation for IR layer. From the dissolution data of floating bilayer tablets of Pindolol, B2 (IR4&SR2) has shown good drug release. SR2 contain Carbopol 940(Synthetic Polymer). Formulations containing Eudragit S100 and L 100 retard the drug release more than 12 hours hence those formulations did not take into consideration. B19 formulation was shown best drug release (97.88%) within 12 hours which contains Caragennan(Natural polymer). Finally Concluded that B19 formulation was optimised formulation. B19 Formulation contains IR4 immediate release and SR19 sustained release formulation blend. SR19 which follows zero order release kinetics.

Keywords: Pindolol, IR layer, Direct compression, SR floating layer, Wet granulation method, Floating bilayer tablets.


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