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Abstract

FORMULATION, CHARACTERIZATION AND EVALUATION PARAMETERS OF FAST DISSOLVING TABLETS OF ONDANSETRON HCL

Y.Ganesh Kumar1*, M.Sindhu Reddy2, P.Nithin Kumar3, SK.Nayab Rasool4, K.Srinivasulu4

1Research Scholar, Faculty of Pharmaceutical Sciences, JNTU Hyderabad, A.P, India
2T.John College of Pharmacy, Bangalore, K.A, India.
3Vikas College of Pharmacy, Shameerpet, Jangaon, Warangal, A.P, India.
4Srivani School of Pharmacy, Chevuturu, Vijayawada, Krishna.Dist, A.P, India.

ABSTRACT

Ondansetron is a Serotonin 5-HT3 Receptor antagonist used mainly as an Antiemetic Drug. It affects both peripheral and central nerves. Ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone. Ondansetron is well absorbed after oral administration and undergoes limited first-pass metabolism. Oral bioavailability of 60% due to hepatic first pass metabolism and has a short half-life of 5.7 hours. And Plasma Protein binding is a 70-76%.The present study was carried out to formulate and evaluate fast dissolving tablets of Ondansetron hydrochloride for Oral administration. The prepared powder blends were then compressed into tablets using the necessary Superdisintegrants and Excipients. The tablets were evaluated for Weight variation, thickness, hardness, friability, Drug Content and Disintegrating Time (Sec) were subjected to a 9 minutes in vitro drug release studies (USP dissolution rate test apparatus II, 50 rpm, 370C 0.50C) using phosphate buffer, pH 6.8 as a dissolution medium (900ml). The amount of Ondansetron released from the tablet formulations at different time intervals was estimated using a UV spectroscopy method. The formulations that showed a considerable retardation of the drug release are considered promising. Among the Eight formulations, F5 formulation containing Drug to Sodium Starch Glycollate (SSG) in ratio 1:1 is optimized based on its ability to till 9 minutes of invitro dissolution time, and its % Cumulative Drug Release is 98.27%.

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