A STUDY OF THE EFFECT OF HYOSCINE BUTYL BROMIDE ON THE DURATION OF LABOUR
Sreelatha S, Vedavathy Nayak*, Gayathri C , Renuka Ramaiah
ABSTRACT
Objective: The purpose of this study was to assess whether hyoscine
butyl bromide is effective in improving cervical effacement and
dilatation, thus reducing the duration of first stage of labour without
causing any maternal and neonatal complications. Materials and
Methods: It was a prospective, comparative, observational study. 80
women with term pregnancies in active labour were recruited for the
study. They were allocated into 2 groups, study and control group each
with 40 patients. The duration of active labour was taken from 3 cm
dilatation to full dilatation of the cervix. The study group received 40
mg HBB as slow I V injection (over 1 – 2 min) given at hourly
intervals up to a maximum of 3 doses starting at 3 cm dilatation.
Results: The mean duration of active phase of labour was 109.28 ± 58.
42 minutes in the study group and 317.48 ± 108.9 in the control group. The difference
between the 2 groups was statistically significant (p< 0.001). In 25 (62.5%) women, the onset
of active labour to delivery interval was < 2 hours in the study group whereas it was only 2
(5%) in the control group. Similarly 2 (5%) women took > 4 hours after first injection of
HBB to deliver whereas 29 (72.5%) women took > 4 hours after onset of active labour to
deliver in control group (table 5). This was statistically significant (p < 0.05). There was no
difference in the APGAR scores in the 2 groups. No significant adverse effects were noted in
the group of women receiving HBB. Conclusion: HBB is a safe drug and is effective in
significantly reducing the duration of labour.
Keywords: first stage, hyoscine butyl bromide (HBB), labour, cervical dilatation.
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