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Abstract

CARDIOPROTECTIVE EFFECT OF PERSEA AMERICANA MILL FRUIT EXTRACT IN EXPERIMENTAL MYOCARDIAL INFARCTION

Manal A Emam* and Marwa G.A. Hegazy

ABSTRACT

We aimed to investigate the protective effect of avocado fruit extract
(AVOE) and elucidate its mechanisms on isoproterenol induced
myocardial infarction in rats. The biochemical markers for myocardial
infarction, antioxidant status on heart tissue, the histopathological
examination of heart tissue and the genes expressions levels of nitric
oxide synthase (NOS), nuclear factor-kappa B (NF-kB) and tumor
necrosis factor-alpha (TNF-α) were all evaluated. Pretreatment with
avocado followed by isoproterenol injection significantly prevented
almost all the parameters of isoproterenol induced myocardial
infarction. Results were confirmed by the histopathological
examination. No significant change was observed in the baseline
group. Avocado pretreatment upregulated the expression of endothelial
nitric oxide synthase, whereas expressions of nuclear factor-kappa B and tumor necrosis
factor-alpha were downregulated in isoproterenol-treated rats. This suggests that the
protective effects of avocado fruit extract may be mediated through upregulation of nitric
oxide production, antioxidant mechanisms, and its ability to inhibit TNF-α and NF-kB.

Keywords: Myocardial infarction, Avocado, tumor necrosis factor-alpha, nuclear factorkappa B.


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