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Abstract

THE EFFECT OF AQUEOUS EXTRACT OF XYLOPIA AETHIOPICA (NIGRO PEPPER) ON SOME HAEMATOLOGICAL PARAMETERS IN ALBINO RATS

Obembe A.O., *Ofutet E. O., Okpo-ene A.I., Okon V.E., Eyong E. E.

ABSTRACT

The effect of xylopia aethiopica on some haematological parameters in albino rats was studied. Thirty albino rats were randomly assigned into 3 groups, n =6. Group one served as control, group 2 received low dose of extract (100mg/kg body weight), while group 3 received high dose of extract (200mg/kg body weight). All animals had free access to feed and water ad libidum. The feeding lasted for 28 days and was done with the aid of an orogastric cannula. At the end of the 28 days, blood samples were collected and analyzed. Results shows no significant change in red blood cell count, packed cell volume, mean corpuscular haemoglobin, and MCV. WBC, Hb and MCHC was significantly lower (p<0.05 and p<0.01) in the low dose group, while clotting and bleeding time were significantly higher (p<0.05 and p<0.01) in the high dose group. In conclusion, aqueous extract of xylopia aethiopica lower haemoglobin concentration at low dose, lowers white blood cell count, lowers mean corpuscular haemoglobin, increases bleeding time and clotting time, hence care should be taken when using xylopia aethiopica as it may be detrimental to our blood system.

Keywords: Xylopia aethiopica, blood cell, clotting time, bleeding time, white blood cell.


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