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Abstract

LINEZOLID RESISTANCE AMONG STAPHYLOCOCCUS HAEMOLYTICUS ISOLATED IN BAGHDAD CITY

Mustafa S. Al-Salmani*, , Tuqa S. Al-Salmani, Khairiyiah J. Al-Khataua

ABSTRACT

Linezolid is an oxazolidinone antibiotic in clinical use for the treatment
of serious infections of resistant Gram-positive bacteria.
Staphylococcus haemolyticus considered as the most antibioticresistant
CoNS species. The aim of this study was to identify the
linezolid susceptibility among S. haemolyticus isolates which isolated
from Iraqi patients. Among 120 Staphylococcus isolates isolated from
blood cultures, 46 isolates were identified as S. haemolyticus during
2014 -2015. Only two isolates were resistance to linezolid at all
Linezolid used concentrations (i.e., 2μg/ml, 4μg/ml, 8μg/ml and
20μg/ml), the rest (95.65%) were sensitive to it at 2μg/ml. The
susceptibility of ten representative isolates (8 sensitive to linezolid and
2 resist to it) showed the highest resistance recorded to Erythromycin as 10 isolates from 10
(100%), which appeared to be due to methylation mechanisms in 9 isolates and one isolate
due to other mechanism. Resistance to Clindamycin and Chloramphenicol was recorded.

Keywords: Linezolid Resistance, Staphylococcus haemolyticus, Baghdad City, Iraq.


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