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Dr. Muhammad Baqir MR Fakhrildin
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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF LEVOFLOXACIN HEMIHYDRATE AND ORNIDAZOLE IN COMBINED DOSAGE FORM BY ABSORBANCE RATIO METHOD

Shweta B. Pednekar* and Sachi S. Kudchadkar

ABSTRACT

A new UV spectrophotometric absorbance ratio method was developed and validated for the simultaneous estimation of Levofloxacin Hemihydrate (levo) and Ornidazole (orni) in pure and pharmaceutical dosage form. Levo shows λmax at 288 nm and orni at 317 nm and an isosbestic point at 305 nm in deionized water. The developed method was found to show linearity in concentration (conc.) range of 1-11 μg/ml for levo and 2-22 μg/ml for orni with the value of correlation coefficient (R2) 0.9981 and 0.9969 respectively. The percent Relative Standard Deviation (% RSD) of inter and intra-day precision studies were found to be within limits of NMT 2 % concluding that the present method is precise as per ICH guidelines Q2 (R1).[1] The developed method can be used for routine estimation of levo and orni in bulk and pharmaceutical dosage form.

Keywords: UV spectrophotometry, Levofloxacin Hemihydrate, Ornidazole, Absorbance, Absorptivity.


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