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Abstract

THE INFLUENCE OF pH ON DRUG RELEASE FROM STAVUDINE HYDROPHILIC MATRICES CONTAINING DIFFERENT GRADES OF HYDROXYPROPYL METHYL CELLULOSE

Masheer Ahmed Khan*

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore, 452001, India.

ABSTRACT

The present study examines the effect of multimedia dissolution profile on the drug release of sustained release hydrophilic matrices of stavudine containing combination of different grades of hydroxypropyl methylcellulose. Stavudine is a thymidine analog currently approved by US-FDA for the treatment of HIV. Hydrophilic matrices were prepared using combination of different grades of HPMC viz. HPMCK4M and HPMCK15M to sustain the release of the drug. Multimedia dissolution studies were performed to mimic the in-vivo condition by doing in-vitro test. The pH/buffer selection is based on the exposure of drug from stomach to intestine/colon. The study ensures the impact of pH changes on dissolution and release of drug substance for absorption. Hydrophilic matrices of stavudine also provide quite regulated release of the drug over an extended period of time.

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