WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

EFFECT OF TARTRAZINE ON ACID AND ALKALINE PHOSPHATASES IN THE LIVER OF ALBINO RATS

Veena B. Kushwaha* and Geeta Bharti

ABSTRACT

Tartrazine (E102, Trisodium (4E)-5-oxo-1-(4-sulfonatophenyl)-4-[(4- sulfonatophenyl) hydrazono]-3-pyrazolecarboxylate) is a synthetic lemon yellow azo dye, water soluble and commonly used as food coloring agent all over the world. Hence, this study is aimed on estimation of the variation in the activity of enzyme acid and alkaline phosphatase in the liver of both male and female albino rats after exposure to sub lethal oral doses (100, 200 and 400mg/kg body weight) for 28 days. A non-significant increase in the activity of acid phosphatase after 7 and 14 days, while a significant (p<0.05) increase in the activity of acid phosphatase after 21 and 28 days in female and male rats treated with 100 and 200 mg/kg body weight of Tartrazine in comparison to control was observed. A significant (p<0.05) increase in the activity of acid phosphatase was observed in both male and female rats in comparison to control rats, on exposure to 400 mg/kg body weight of the Tartrazine. A significant decrease in activity of alkaline phosphatase after 14, 21 and 28 days in animals treated with 100 mg/kg body weight, after 7, 14, 21 and 28 days in animals treated with 200 and 400 mg/kg body weight of Tartrazine in comparison to control animals was observed. Variation in the strength of dose and exposure time significantly influences the activity of acid and alkaline phosphatase in both male and female rats, suggesting induction of liver dysfunction and change in permeability of the membrane of hepatocytes.

Keywords: Food additive, Color additive, Tartrazine, Hepato-toxicity, Acid Phosphatase and Alkaline Phosphatase.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More