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Abstract

COMPARATIVE STUDY OF ANTI-HYPERLIPIDEMIC EFFECT OF ZINGIBER OFFICINALE,MOMORDICA CHARANTIA, TRIGONELLA FOENUM-GRAECUM, DILLENIA INDICA AND TAMARINDUS INDICA.

Asif Alam Chowdhury, Abhijit Sukul*, Imdadul huque khan, Yasir Mamun, Imran Chowdhury and Sheikh Zahir Raihan

ABSTRACT

This dissertation aimed to compare the antihyperlipidemic effects of methanolic extract of Zingiber officinale, Momordica charantia, Trigonella foenum-graecum, Dillenia indica and Tamarindus indica in hyperlipidemic animal models. Atorvastatin was used as standard drug. The crude extract (100 mg/kg) of these significantly prevented the increase in low density lipoprotein (LDL), total cholesterol (TC), triglyceride (TG) and significantly increased the HDL level in blood serum. The reduction in serum level of above parameters was compared with atorvastatin and then within themselves. Among the five samples, Zingiber officinale extract showed significant Cholesterol reduction property (p<0.001) compared to other extracts. Momordica charantia & Dilenia indica (p<0.001) significantly increased the blood HDL cholesterol level. Zingiber officinale, Dilenia indica & Tamarindus indica significantly reduced LDL level in blood (p<0.001). Momordica charantia & Trigonella foenum-graecum significantly reduced TG level (p<0.001) in blood serum of rats. So, the above results confirmed that all extracts are potent against hyperlipidemia.

Keywords: Atorvastatin, LDL, TC, TG, HDL, Hyperlipidemia.


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