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Abstract

ANTI-UROLITHIATIC ACTIVITY OF METHANOLIC EXTRACT OF ROOTS OF “CARICA PAPAYA’’ LINN IN ETHYLENE GLYCOL INDUCED UROLITHIATIC RATS

S. Vijayakumar1, C. Velmurugan*2, P.R. Logesh kumar3 and SK. Shajahan2

1Department of Pharmacognosy, Sri Krishna Chaithanya College of Pharmacy, Gangannagaripalle, Madanapalle, Andhra Pradesh-517325.
2Department of Pharmacology, Sri Krishna Chaithanya College of Pharmacy, Gangannagaripalle, Madanapalle, Andhra Pradesh-517325.
3Department of Pharmaceutical chemistry, Sri Krishna Chaithanya College of Pharmacy, Gangannagaripalle, Madanapalle, Andhra Pradesh-517325.

ABSTRACT

The present study was undertaken to evaluate the antiurolithatic effects of the methanolic extract of the root of Carica Papaya (CP) on ethylene glycol (EG) induced urolithiatic rats. Rats were given 0.75% v/v EG administration resulted in hyperoxaluria as well as increased renal excretion of calcium, oxalate and phosphate. Extract and cystone treated groups revealed increase the urine output, urinary pH and serum calcium level when compare to EG induced control. Methanolic extract of C. papaya root significantly (p<0.05) lowered the elevated urinary concentration of calcium, oxalate and phosphorus and also serum level of blood urea nitrogen, creatinine and uric acid. The increased deposition of stone forming constituents in the kidneys of urolithiatic rats was also significantly lowered by preventive treatment using methanolic extract of the roots of C. papaya. The results indicate that the root of C. papaya is consummate with antiurolithiatic activity like fruit which has been proved by earlier studies.

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