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Puja Buwade*, Shailendra Jadiya, Tripti Shukla and Dr. Neeraj Upmanyu


In the present time most common and widely useful route of administration of maximum drug is oral route; in which tablet form is widely used dosage form over the other dosage form because of selfadministration and ease in formulation. Mostly drug are available with BCS class III & IV, so there should be the first main target to develop a formulation with increasing solubility & permeability. Mostly Drugs have half-life of is about 1.5 to 3 days. So there is another essential need to devolvement a formulation of such poorly water soluble drug with different approaches to enhance bioavailability of the drug. There is also need of rapid dissolution and absorption of drug, which may produce rapid onset of action. Immediate release tablets fulfill these all requirements over the other dosage forms. But after the formulation of product, improper drug release is another problem & improper distribution of drug in blend power during granulation, is the second major problem. Different techniques such as direct compression, dry granulation and wet granulation can be used for formulation of tablets. Proper amount of diluents, disintegrating agents & lubricants in immediate release tablet preparation, become important step to achieve desired bioavailability within desired time. Mostly Pharmaceutical products are available for oral delivery and also available for the prescription and over-thecounter markets, which are the immediate release dosage forms, these dosage forms are only for immediate release of the drug for rapid absorption & rapid onset of action.

Keywords: Immediate release, solubility, dissolution, disintegration agents.

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