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Abstract

EVALUATION OF COMPATIBILITY BETWEEN DICLOFENAC SODIUM, ISOLATED NOVEL FICUS PALMATA MUCILAGE AND SOME OTHER PHARMACEUTICAL EXCIPIENTS

Yogesh Joshi* and Kaushal Kishore Chandrul

ABSTRACT

The study was undertaken to evaluate the compatibility between diclofenac sodium, isolated novel plant mucilage, and some other pharmaceutical excipients, using physicochemical compatibility study and fourier transform infra red (FTIR) spectral study. Physicochemical compatibility study was carried out by observing any physical or chemical changes in the form of incompatibility in two combination mixtures in different storage conditions. All combinations, kept on glass vials, were stored at 4ºC, Room Temperature (RT) and 40ºC under observation. There were no characteristic changes shown by any of the mixture after every week intervals in different storage conditions. There were no sign of any incompatibility between diclofenac sodium, Ficus palmata mucilage and other excipients after FTIR spectral analysis. Therefore, such combinations can be best suitable in formulating any type of dosage forms for administration.

Keywords: Diclofenac sodium, Ficus palmata, Compatibility, Excipients.


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