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Abstract

ANTINOCICEPTIVE AND ANTI-INFLAMMATORY POTENTIALS OF 80 PERCENT METHANOL SOLUBLE FRACTIONS OF AQUEOUS ROOT EXTRACTS OF THREE VIBURNUM LINN. SPECIES

Kathiresan Ponnudurai*, Kathiresan Prabhu, M. Srinivasa Murthy

ABSTRACT

The genus, Viburnum Linn., belonging to the family Caprifoliaceae includes about 200 species throughout the world and some 17 species growing in India at an altitude from 1800 – 2500 ft. Many of these species have been investigated for their pharmacognostic features and phytochemical elaboration lacking information on biological potentials of them. So, the current study undertaken casts some scientific information on phytochemical based pharmacological screening such as anti-inflammatory and analgesic activities, using Methanol soluble fractions of aqueous root extracts of three species – Viburnum punctatum Buch.-Ham. ex D. Don (VPMF), Viburnum coriaceum Blume (VCMF) and Viburnum erubescens Wall. ex DC (VEMF) – in suitable animal models. The acute oral toxicity study was carried out according to the OECD (Organization for Economic Co-operation and Development) guidelines 423 (Acute toxic class method). In acetic acid induced writhing in mice, a significant reduction in writhing was observed with all the fractions than the control group (p<0.001) which received 1% CMC. However, reduction in number of writhings was not proximal to the standard (Diclofenac sodium 15mg/kg b.w, p.o). In cotton pellet induced granulation method in wistar rats, a significant reduction in dry weight and wet weight of cotton pellets was observed with all the three fractions (500mg/kg b.wt) (p<0.001) which was comparable to that of the standard (Indomethacin 20mg/kg b.w, p.o).

Keywords: Viburnum, phenolic compounds, ED50, OECD, anti-inflammatory.


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