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Abstract

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NOVEL HYDRAZONE DERIVATIVES OF ANTHRANILIC ACID

Adinarayana Reddy Ragipindi*, Krishna Reddy Vanka, Ram Bhavani, Balram Bhavani

ABSTRACT

This paper describes the synthesis, characterization and antibacterial evaluation of some new N acylhydrazone(NAH) compounds 5a-j, (E)- N'-(substituted-benzylidene)-2-(benzamido)benzohydrazides, derived by the condensation of different aldehydes with acid hydrazide of Nbenzylanthranilic acid 4. The structures of the newly synthesized compounds were ascertained on the basis of 1H NMR, mass and IR data. All the compounds have been evaluated for their antibacterial activity against (i) Staphylococcus aureus (MTCC 96), (ii) Streptococcus pyogenes (MTCC 442), (iii) Escherichia coli (MTCC 443) and (iv) Pseudomonas aeruginosa (MTCC 424) by agar well diffusion method. Most of the compounds showed good to moderate activity. Compounds 5b, 5c, 5g and 5j exhibited good antibacterial activity against the tested bacterial strains.

Keywords: Anthranilic acid, Hydrazones, Synthesis, Antibacterial activity, Agar diffusion.


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