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Abstract

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF GLIBENCLAMIDE AND METFORMIN HCL IN BULK AND TABLETS USING UV – VISIBLE SPECTROSCOPY

Bhavika R. Chavhan*, P.B. Patil, S. R. Bavaskar, Dr.S. D. Barhate.

ABSTRACT

Two simple, precise and economical UV methods have been developed and validated for the simultaneous estimation of Glibenclamide and Metformin hydrochloride in bulk and pharmaceutical combined dosage form. The method employed simultaneous equation method for analysis using 0.01N NaOH as a solvent. The two wavelengths 226.60nm and 233 nm were selected for estimation of Glibenclamide and Metformin HCl respectively. Linearity was observed in the concentration range of 2-10μg/ml for both Glibenclamide and Metformin HCl respectively. The recovery studies ascertained the accuracy of the proposed method and the results were validated as per ICH guidelines. The method can be employed for estimation of pharmaceutical formulations with no interference from any other excipients and diluents.

Keywords: Glibenclamide, Metformin HCl, Simultaneous estimation.


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