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*Royana Singh, Jasmeet Singh, Jyoti Prakash Pani, Anil Kumar Singh, Shivji Gupta


―Kshara karma (application of caustic alkaline paste) has been used in Ayurveda to treat Hemorrhoids from Sushruta period. Arsha (hemorrhoids) is commonly resides in anal region (Gudasthan) mostly at 3, 7& 11‗o‘ clock position with bleeding tendency. In modern era Kshara karma is not very popular procedure among the physicians and study about this is very less especially at histological level. Therefore, the present work carried out an experimental work in vivo in a mouse model to see the effect of ―Kshara karma‖ by evaluating the histological sections performed at the, 2nd, 4th, 6th and 8th days after treatment with Kshara (application of caustic alkaline paste) and it‘s neutralized with lime fruit juice. Because Teekhna kshara plays pivotal role for making famous Ayuvedic Surgeon in the aspect of treating piles mass. The histological sections were analyzed with regard to inflammatory response and vascularization followed by liberation of slough tissue and healing with granulation and fibrosis of the local area of affection at the end. Kshara karma displayed increased Inflammation with vascularization during the first 6 days of treatment compared to the control animals treated with normal saline the same time period. The number of inflammatory cells (neutrophils) was dissimilar in both groups during the period, significantly reducing at the end of inflammatory phase (3th day of treatment). The reduction is consistent with the progression of healing process from 6th to 8th day. In addition, the density of blood vessels was also statistically dissimilar in both matrices.

Keywords: Arshas, Internal hemorrhoids Kshara karma, Piles, Swiss albino mice.

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