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Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF ACECLOFENAC TRANSDERMAL GEL- A NOVEL APPROACH FOR PENETRATION ENHANCEMENT BY HERBAL EXTRACT

Singh Rampal*, Juyal Divya, Singh Vikram and Rawat Geeta

ABSTRACT

The present research has been undertaken with the ambition to formulate, optimize and evaluate the gel containing acorus calamus oil. The gel was prepared by using aceclofenac (API) and optimum ratio of carbopol 941 P and HPMC K15 M and other excipients are propylene glycol, triethanolamine, and methyl paraben. The aceclofenac permeability through stratum corneum occurs by using oil which obtained from the leaves of acorus calmus. The acorus calamus oil was used as a penetration enhancer. All prepared gel formulations were evaluated by pH, spredability, extrudability, viscosity, drug contents, in- vitro permeability studies and drug- polymer compatibility (FTIR studies). The absorption maxima of aceclofenac were found at 273 nm using ph 6.8 phosphate buffer solutions. The pH values of all formulation was in the range between 6.80 -7.23. Drug content of all formulation ranges from 82.72 - 90.22. The result value of spreadability was range from 11.66 - 14.66(gm. cm / sec). Whereas the extrudability value of gel formulations from the collapsible tube varies range from 250.00 to 444.44(gm.cm2) and the viscosity of formulations ranges from 21023 cps to 22101 cps at 50 rpm. The % cumulative drug release range from 48.50 -66.78% in 6 hr.

Keywords: Acorus calamus, API, FTIR, in- vitro permeability studies.


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