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Abstract

OPTIMISATION OF COMPRESSION FORCE AND LUBRICANT MIXING TIME FOR THE ORODISPERSIBLE TABLET BY DESIGN OF EXPERIMENT APPROACH

Kapil Joshi, Abhay Asthana*, Gyati Shilakari Asthana and Subhash Pande

ABSTRACT

A two factor, three level (32) face full factorial design was used to study the effects of compression force (CF) and lubricant mixing time on disintegration time (DT) and hardness of amlodepine-ramipril orodispersible tablets (ODTs). Orodispersible tablets were prepared by direct compression. Multiple linear regression analysis was used for generation of polynomial equation and optimization of formulation. Results of multiple linear regression analysis indicated that both the factor affect tablet properties. The optimized level of independent variables; compression force (138.54 MPa) and lubricant mixing time (2.59 min) provided a rapid disintegration (30.0 sec) with optimum hardness (3.5 kg/cm2).

Keywords: Design of experiment, orodispersible, 32factorial design, process variables, optimization.


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