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Abstract

IN-VIVO STUDIES ON ANTI RHEUMATOID ACTIVITY OF INDIAN MEDICINAL PLANT

B. Babu Rao* and V. Shashanka

ABSTRACT

The present work was undertaken in order to evaluate and anti-arthritic potential of whole plant of Cuscuta reflexa The study was aimed at carrying out the pharmacological screening of ethanolic extract of whole plant of Cuscuta reflexa for anti-arthritic activity which was evaluated by in-vivo Adjuvant- induced arthritis model in rats by analyzing the some parameters. Bone destruction, which is a common feature of adjuvantarthritis, was examined by radiological analysis. Gross destruction of the joints of the untreated paws was observed in5 out of 6 rats in the adjuvant control group. in rats given ethanolic extract of Cuscuta reflexa attenuate these abnormalities predominantly localized to the proximal areas of the paws (Table 5). Ethanolic extract at 200mg/kg dose alone failed to produce any significant improvement. Ethanolic extract at 400 mg/kg dose alone should produce slightly good significant improvement than before dose. Total white blood cells (WBC) count increase with significantly increased in arthritic animals. ESR and RF were also significantly increased, while hemoglobin, red blood cells (RBC) was decreased in AIA animals. Results shown in below table 6 suggest that total WBC count, ESR and RF are significantly decreased, while hemoglobin, RBC was slightly increased in treated animals in dose-dependent manner as compared to disease control (P <0.01).

Keywords: Anti-arthritic activity, RBC, WBC, NSAIDs.


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