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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF LABETALOL HYDROCHLORIDE USING NATURAL AND SYNTHETIC POLYMERS AND COMPARISON OF RELEASE RETARDING PROPERTY OF POLYMRS.

Nilam Krishana Thakare*

ABSTRACT

Labetalol hydrochloride is used in treatment of hypertension. It has a short half life and undergoes extensive first pass metabolism. In present study matrix tablets of Labetalol HCL were prepared by direct compression method using HPMC K100 as synthetic polymer, Xanthan gum and Guar gum as natural polymers. All these prepared formulations were evaluated for weight variation, hardness, thickness, drug content and drug release pattern which showed satisfactory results. In-vitro drug release was carried out using USP Type II dissolution apparatus at 50 rpm in 900 ml of acidic dissolution medium (pH 1.2) for 2 hours, followed by 900 ml phosphate buffer medium (pH 6.8) up to 12 hours. Among all the formulations F-6 and F-13 showed better release and could extend the release up to 12 hours. When natural polymers like Xanthan gum and Guar gum used in combination in different concentration ranges, their drug release retarding property get increased as compared when they are used in single. Several kinetics models were applied to the dissolution profiles to determine the drug release kinetics.

Keywords: Labetalol Hydrochloride, HPMC K100, Xanthan Gum, Guar Gum.


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