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Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF ONS DONOR N-4-DISUBSTITUTED THIOSEMICARBAZONE LIGAND AND ITS TRANSITION METAL COMPLEXES

Vrushali S. Gavhane, Vijayanand D. Ingale, Vishal G. Shinde, Anjali S. Rajbhoj, Suresh T. Gaikwad*

ABSTRACT

Four novel transition metal complexes Cr(III), Mn(II), Co(II) and Ni(II) of 1-(2-hydroxybenzylidene)-4-ethyl-4-phenylthiosemicarbazide (HEPT) have been synthesized and characterized by elemental, spectroscopic (FTIR,1H-NMR), molar conductivity and X-ray diffraction studies. The FTIR spectral data suggested the attachment of central metal ion to ligand moiety through the azomethine nitrogen, thioketonic sulphur and phenolic oxygen. The molar conductance measurements of the complexes in DMSO determines electrolytic nature of Cr(III), Mn(II) and Co(II) complex, while Ni(II) complex is nonelectrolyte in nature. On the basis of spectral studies an octahedral geometry may be assigned for all four complexes. The HEPT ligand and its transition metal complexes have been tested for their antibacterial activity against Staphylococcus aureus, Bacillus substilis species and antifungal activity against Aspergillus niger and Fusarium oxysporum species at 250 ppm and 500 ppm concentration. All complexes showed considerable activity almost equal to the activity of ciprofloxacin.

Keywords: N-4-Disubstituted-3-thiosemicarbazone, XRD, Biological activity.


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