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Abstract

ROLE OF ROWATINEX IN THE TREATMENT OF RENAL STONE AFTER EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY

Haider Raheem Mohammed, Inam Sameh Arif, Hadeel Delman Najim*, Manal Khalid Abdulridha

ABSTRACT

Background: the efficacy of medical therapy after ESWL has been demonstrated to facilitate and accelerate the expulsion of renal stones. Our aim was to evaluate the effect of Rowatinex, an essential oil preparation of terpenic type, on kidney stone clearance after ESWL. Patients and methods: from March to September 2015, 30 patients age (20-60years old) with renal stone presented to Ghazi Al-Hariri Hospital for surgical specialist in Baghdad, Iraq were enrolled in this randomized single-blind study. All patients were examined by ultrasonography and IV urography. All patients were exposed to Extracorporeal Shock Wave Lithotripsy (ESWL) and then randomly divided into two groups: first group received Rowatinex 1 capsule (100mg) before food three times daily, and second group of 15 patients received starch as placebo and served as control group. The medication starts immediately after ESWL and followed up at 4, 8 and 12 weeks post-ESWL. Clinical success defined as total clearance of stone or clinically insignificant stone. Results: four weeks following ESWL (13.3%) and (6.7%) of the patients in Rowatinex group and control group had total stone clearance. After eight weeks the percentage raised to (53.3%) for Rowatinex group and (33.3%) for control group, the differences between two groups was not significant (p>0.05). after twelve weeks (93.3%) of the patients in Rowatinex group showed total stone clearance versus (80%) in control group, the difference between the groups still non-significant (p>0.05). The elevated stone free rate reported from fourth and twelfth week was significant (p<0.05). Conclusion: Rowatinex does not have a significant effect on clearance rate of kidney stones after ESWL. However, Rowatinex achieved calculus clearance in larger number of patients and showed a significant faster rate of clearance which means Rowatinex can accelerate stone passage after ESWL.

Keywords: ESWL; Renal stone; Rowatinex.


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