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Abstract

SYNTHESIS OF SOME NOVEL BIOACTIVE POLYHYDROXY CHALCONES

Nana V. Shitole, Suraj B. Ade and Subhash M. Lonkar*

ABSTRACT

A series of novel 1-(2'-hydroxy substituted phenyl)-3-(-2'-hydroxy substituted phenyl)-2-propen-1-ones were synthesized by Claisen Schmidt condensation of -2'-hydroxy substituted acetophenone and 2' - hydroxy substituted arylaldehyde in alkaline medium KOH and ethanol. An excellent yield 75-80 % were obtained in bulb oven at 55- 600C after 14-16 hrs. The compounds were found to have antimicrobial activity.

Keywords: Polyhydroxychalcones, 2'-hydroxy acetophenone, 2'- hydroxy arylaldehyde, antimicrobial activity.


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