WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Akele Richard Yomi*, Olayanju Ayodeji Olusola, Bala Ntuhun Dennis, Chollom Solomon Chuwang, Enitan Samson Seyi. and Irec Jacob.


Highly active antiretroviral viral therapy (HAART), a combination of three antiretrovirals from at least two drug classes for optimization of hindrance to HIV replication has greatly increased life expectance. There however, exist numerous of these combinations and thus the questions of which is the best HAART combination with respect to the individual’s haematological status. To investigate this, blood samples were collected from 231 retropositive subjects on six different HAART combinations at least six months after HAART commencement, assayed for CD4 and some haematological parameters using cyflow and sysmex(KX-21) autoanalysier. Baseline data was accessed from the LAMIS data base. The difference between baseline and values after HAART was taken and statistically compared. HAART evaluated includes, Combivir(NVP), Combivir(EFV), Truvada(NVP), Truvada(EFV), Lanten(NVP) and Lanten(EFV). The difference in the parameters assayed are: CD4(cellmm-3): 154, 205, 172, 206, 262, and 230(P=0.478). Haemoglobin(gdl-1): -0.78, -0.73, 2.35, 1.48, 1.11 and 1.27(P=0.010). PCV(%): -2.34, -2.19, 7.65, 7.02, 3.36 and 3.12(P=0.0001). WBC(103μl-1): -1.19, -1.02, - 0.37, 0.06, 1.14 and -0.63(P=0.001). Neutrophil(%): -1.51, -1.83, 3.87, 2.07, 2.71, 2.71 and 1.97(P=0.868). Lymphocyte(%): -4.26, -2.87, -1.45, -0.19, 2.36 and 3.40(P=0.790). Eosinophil(%): -0.41, 0.14, -2.65, 0.14, -0.46 and 0.12(P=0.094). Platelet(103μl-1): -49, -39, -53, -53, -47 and -35(P=0.931). The Zidovudine based combinations showed anaemic tendencies; Nevirapen based combinations showed Eosinopenic tendencies. All HAART used induced good immunologic responses along with thrombocytopenic tendencies. The data generated was however insufficient to discriminate one combination as being better than the other, rather it was observed that the haematological profile of clients must be well considered when selecting HAART.

Keywords: HIV, anaemia, thrombocytopenia, HAART, haematotoxicity, CD4 cells.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More