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Abstract

THE ROLE OF SERUM AND FOLLICULAR FLUID GHRELIN HORMONE IN POLYCYSTIC OVARY SYNDROME PATIENTS UNDERGOING ICSI

Prof. Dr. Nawal Khairy AL-Ani? and Dr. Hiba Sadoon Mhawis?.

ABSTRACT

Background: Ghrelin is a 28 amino acid gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor, mainly produced by a subset of stomach cells and also by the hypothalamus, the pituitary, and other tissues . The Ghrelin receptors can also be found in ovarian tissue, thus suggesting a possible reproductive function of this hormone. The objective of this study was to estimate the effect of ghrelin hormone level in serum and follicular fluid in PCOS patient at day of ova pick up in predicting pregnancy outcome after intra cytoplasmic sperm injection. A total of 90 infertile women(60 women with Poly cystic ovary syndrome and the other 30 women as a control)undergoing controlled ovarian hyperstimulation for intracytoplasmic sperm injection cycle were prospectively recruited for this study in center of fertility and in vitro fertilization at Kamal AL_Samarai Hospital (Baghdad/Iraq)during the period from September 2014 to the end of February 2015. All patients underwent a long standard gonadotrophin releasing hormone agonist protocol(GnRH-a). Serum and follicular fluid ghrelin hormone levels were measured on the day of oocyte retrieval by using Enzyme linked immuno sorbent assay. The concentration of serum ghrelin hormone was lower in poly cystic ovary syndrome patients than in control patients(6.81±0.44,12.09±0.28)pg/ml respectively. There was no significant correlation between serum and follicular fluid ghrelin hormone(r=0.04,p=0.660).E2 level in both serum and follicular fluid were highly significant increase(p<0.001)in PCOS than control group Regarding pregnancy rate it was higher in PCOS patients(23.33%) than in control patients(10%). We can conclude that the level of ghrelin hormone at day of oocyte retrieval in both serum and follicular fluid, cannot be used as a strong test in predicting pregnancy after intra cytoplasmic sperm injection cycles.

Keywords: ghrelin, PCOS, ICSI.


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