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Abstract

THE ROLE OF SERUM AND FOLLICULAR FLUID RESISTIN IN ASSESSING THE PREGNANCY OUTCOME IN PATIENT WITH PCOS

Prof. Dr. Nawal Khairy AL-Ani*, Dr. Rabab AlwanTaher, Dr. Thuraya Husamuldin Abdullah

ABSTRACT

The hormone resistin, a cysteine-rich protein, is secreted by adipocytes . Serum resistin levels are significantly increased in insulin-resistant mice and genetically or diet-induced obese mice .In addition, neutralization of endogenous resistin with antibodies significantly suppresses hyperglycaemia in diet induced obese mice by increasing insulin sensitivity. The objective of this study is to compare level of serum and follicular fluid resistin in infertile women with PCOS undergoing IVF\ICSI and to assess possible correlation between resistin and pregnancy outcome.A total of 90 infertile women(60 women with Poly cystic ovary syndrome and the other 30 women as a control)undergoing controlled ovarian hyperstimulation for intracytoplasmic sperm injection cycle were prospectively recruited for this study in center of fertility and in vitro fertilization at Kamal AL_Samarai Hospital (Baghdad/Iraq)during the period from September 2014 to the end of February 2015. All patients underwent a long standard gonadotrophin releasing hormone agonist protocol(GnRH-a). Serum and follicular fluid resistin hormone levels were measured on the day of oocyte retrieval by using Enzyme linked immuno sorbent assay. No significant differences in resistin levels of either serum or follicular fluid between PCOS and control group were found. However, resistin levels in serum were highly significant than that in follicular fluid in both groups.There was a strong positive correlation between BMI and LH(luteinizing hormone)with the resistin in FF and serum. Resistin levels in both serum and follicular did not correlate with estradiol,P4,and testosterone level. No significant correlations were found between reisistin levels and fertilization rate, clinical pregnancy rate in both PCOS and control groups. We can conclude that Resistin is unlikely to be a major determining factor in the growth and maturation of oocytes during IVF-stimulated cycles in PCOS, so it cannot be used as a test in predicting pregnancy after intracytoplasmic sperm injection cycles.

Keywords: follicular fluid/IVF/ICSI/polycystic ovarian syndrome/resistin.


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