WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



*Mumuni A. Momoh, Gwarzo S. Mahmud, Musiliu O. Adedokun, Mba C. Chukwuemeka and A R. Oyi


The objective of the present investigation was to explore the potential of solid dispersions (SDs) for the oral delivery of lumefantrin, a poorly water-soluble antimalarial agent. The SDs containing LMFT were formulated by employing melt fusion technique. Five different ratios of PEG-4000 and LMFT (1:1, 1:3, 3:1, 0:1 and 1:0) were prepared. The SDs was evaluated for particle size, encapsulation efficiency, in vitro drug release. The antimalarial activity of SDs formulated was evaluated in Plasmodium berghei infected mice. Thermograms of the SDs showed modifications in the peaks. Particle sizes of SDs were depend on the ratio of the PEG and drug. The SDs had high drug content and showed sustained release capability as compared to marketed sample. In vivo pharmacodynamic studies showed that LMFT-SDs exhibited significantly higher antimalarial activity (P < 0.05) as compared to the marketed formulation. LMFT-SDs is comparatively better with respect to antimalarial effect, sustained release and survival rate of the animal than marketed sample.

Keywords: lumefantrin, solid dispersion, anti-malaria.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More