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Abstract

IF THERE IS ANY EFFECT OF LOW DOSE AND HIGH DOSE INTRAVENOUS METHYLPREDNISOLONE FOR TREATMENT RELAPSES OF MULTIPLE SCLEROSIS ON ELECTROLYTES IN IRAQI PATIENTS

Zainab Ali Abbood*, May Siddik Al-Sabbagh, Hassan Mohammed Abbas Al-Temimi, Ali Kadim Karim

ABSTRACT

Background: Multiple Sclerosis, a chronic inflammatory and neurodegenerative disease of the central nervous system, characterized by recurrent relapses of central nervous system inflammation ranging from mild to severely disabling. Relapses have treated with steroids to reduce inflammation and hasten recovery. However, the commonly used intravenous methylprednisolone in a dose 500mg_1000mg for 5days. Objectives: The effect of low dose intravenous methylprednisolone (500mg) and high dose (1000mg) for treatment of patients with relapses of multiple sclerosis on electrolytes. Methods: A prospective case controlled study was carried on 40 patients who had multiple sclerosis relapse confirmed by kuratzke expanded disability status scale. Patients were divided into 2 groups first group involved 20 patients treated with (500 mg IV methylprednisolone) for 5 days. The second group involved 20 patients treated with (1000mg IV methylprednisolone) for 5days. Serum sodium, serum calcium and serum potassium before and after 1 and 6 weeks of the study. Results: The results showed that a non-significant difference in serum sodium and serum calcium, while there was a significant decrease in serum potassium level in group 2 after one week of treatment with 1000mg IV methylprednisolone for 5 days in comparison with pretreatment. However, there was a nonsignificant difference in serum sodium, serum calcium and potassium level in group 1 after one week of treatment with 500mg IV methylprednisolone for 5 days in comparison with pretreatment. After six weeks of treatment, there was a non-significant change in serum sodium serum calcium and serum potassium level for patients in both treated groups compared to pre-treatment. In general, after one and six week there were statistically nonsignificant difference among groups in serum sodium, serum calcium and serum potassium level. Conclusion: It seems from this short study that methylprednisolone in a dose of 500mg (IV) daily for 5day to patient with multiple sclerosis had no effect on electrolytes while a dose of 1000mg (IV) for 5 days could cause hypokalemia.

Keywords: Multiple Sclerosis (MS), methylprednisolone, serum sodium, serum calcium and serum potassium.


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