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Roshni Fatma Rizvi* , Gunjan Shrivastava, Pankaj Kumar Singh and Shailendra Kumar Singh


Carrier technology provides an interesting as well as an intelligent approach for the delivery of drug. It offers delivery of drug by coupling the drug to a carrier particle such as microspheres, nanoparticles, liposomes, etc. Microspheres constitute an important part of this particulate drug delivery system because of their small size and other efficient properties. Microsphere are free flowing powder, consist of spherical particle of size ideally less than 1 to 1000 μm. Each particle of microspheres is basically a matrix of drug dispersed in a polymer from which release obtained by a first order kinetic process. In the microsphere, the polymers used are biodegradable and biocompatible. Internal structure of microspheres is a matrix of drug and polymeric excipient. The microspheres are meant to reduce the dosing frequency and improve patient compliance by designing and evaluating sustained release mucoadhesive microspheres for effective control of disease over a longer period of time. Mucoadhesive microsphere exhibit a prolonged residence time at the site of application and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved or better therapeutic performance of drug. Mucoadhesive drug delivery systems promises several advantages that arise from localization at a given target site, prolonged residence time at the site of drug absorption and an intensified contact with the mucosa increasing the drug concentration gradient. Hence, uptake and consequently bioavailability of the drug is increased and frequency of dosing reduced with the result that patient compliance is improved. In recent years such Mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal for either systemic or local effects. Microspheres received much attention for prolonged release and targeting of anticancer drugs. In future by combining various other strategies, microspheres will find the central place in novel gene & genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.

Keywords: Polymer, Natural Mucoadhesive Substance.

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